We are an interdisciplinary research group working at the interface of chemistry and biology. We are particularly interested in developing tool compounds to enrich our current understanding of anti-infectives and modulate protein-protein interactions and advance the drug discovery campaigns against drug-resistant infectious diseases and “undruggable” cancer targets.

We use our expertise in organic synthesis to develop new synthetic methods, discover new chemical reactivity, and functionalize natural products. We use small molecules to probe specific questions in biology and utilize structure-activity relationship studies to optimize small molecules into lead chemotherapeutic agents aimed to combat the growing challenge of antimicrobial resistance and modulate or inhibit proteins that are deregulated in a distinct subset of cancers.