28.  Synthetic Strategies to Access Fluorinated Azoles

Abd El-Gaber, M. K.; Djugovski, M.; Huang, T.-Y.; Adhikari, S.; Roy, S.*

European Journal of Organic Chemistry. 2025, ASAP. DOI: https://doi.org/10.1002/ejoc.202500508

27.  1,2,4-Triazole-based first-in-class non-nucleoside inhibitors of bacterial enzyme MraY

Berida, T.; Huang, T.-Y.; Weck, S.; Lutz, M.; McKee, S.; Kagerah, N.; Manning, D.; Jahan, M.; Mishra, S.; Hermann, J.; Muller, R.; Doerksen, R.; Stallings, C.; Christian Ducho, C.; Roy, S.*

ACS Bio & Med Chem Au, 2025, ASAP. DOI: https://doi.org/10.1021/acsbiomedchemau.5c00158

Non-peer-reviewed version of this article has been posted as a preprint:  bioRxiv 2025. DOI: 10.1101/2025.01.30.635793

26. HuR inhibition reduces post-ischemic cardiac remodeling by dampening myocyte-dependent inflammatory gene expression and the innate immune response

Slone, S.; Anthony, S. R.; Green, L. C.; Parkins , S.; Acharya, P.;  Kasprovic, D. A.;  Reynolds, K.;  Jaggers, R. M.;  Nieman, M. L.; Alam, P.; Wu, X.; Roy, S.; Aubé, J.; Xu, L.; Li, Z.; Lorenz, J. N.; Owens, A. P.; Kanisicak, O.; Tranter, M.

The FASEB Journal. 2025; 39:e70433. DOI:10.1096/fj.202400532RRR

Non-peer-reviewed version of this article has been posted as a preprint: bioRxiv 2023. DOI: https://doi.org/10.1101/2023.01.17.524420

25. Plant antibacterials: The challenges and opportunities

Berida, T.; Adekunle, Y. A.; Dada-Adegbola, H.; Kdimy, A.; Roy, S.; Sarkar, S. D.

Heliyon 2024, 10, E31145. DOI: https://doi.org/10.1016/j.heliyon.2024.e31145

24. Morpholine-mediated defluorinative cycloaddition of gem-difluoroalkenes and organic azides

Huang, T.-Y.; Djugovski, M.; Manning, D. L.; Adhikari, S.; Roy, S.*

Beilstein Journal of Organic Chemistry 2023, 19, 1545–1554. DOI: https://doi.org/10.3762/bjoc.19.111

Non-peer-reviewed version of this article has been posted as a preprint: ChemRxiv, 2023. DOI: https://doi.org/10.26434/chemrxiv-2023-w2r84

23. Discovery, Synthesis, and Optimization of 1,2,4-Triazolyl Pyridines Targeting Mycobacterium tuberculosis

Berida, T.; McKee, S. R.; Chatterjee, S.; Li, W.; Pandey, P.; Tripathi, S. D.; Doerksen, R. D.; Jackson, M.; Ducho, C.; Stallings, C. L.; Roy, S.*

ACS Infectious Diseases 2023, 9, 2282–2298. DOI: https://doi.org/10.1021/acsinfecdis.3c00341

Non-peer-reviewed version of this article has been posted as a preprint: bioRxiv, 2023. DOI: https://doi.org/10.1101/2022.11.14.516356

22. The challenges and opportunities of developing small molecule inhibitors of MraY

Manning, D. L.; Huang, T.-Y.; Roy, S.*

Annual Reports in Medicinal Chemistry, Special Volume on New Approaches Towards Novel Antibacterial Agents project. 2023, 60, 2–159. Invited Review. DOI: https://doi.org/10.1016/bs.armc.2023.09.005

21. Small Molecules Targeting the RNA-Binding Protein HuR Inhibit Tumor Growth in Xenografts

Wu, X.; Ramesh, R.; Wang, J.; Zheng, Y.-G.; Armaly, A.; Wei, L.; Xing, M.; Roy, S.; Lan, L.; Gao, P.; Miao, Y.; Xu, L.; Aubé, J.

Journal of Medicinal Chemistry 2023, 66, 2032–2053. DOI: https://doi.org/10.1021/acs.jmedchem.2c01723

20. HuR-dependent expression of Wisp1 is necessary for TGF-induced cardiac myofibroblast activity

Green, L. C; Slone, S.; Anthony, S. R.; Guarnieri, A. Parkins, S.; Shearer, S. M.; Neiman, M. L.; Roy, S.; Aubé, J.; Wu, X.;  Xu, L., Tranter, M.*

Journal of Molecular and Cellular Cardiology, 2022, Online ahead of print. DOI: 10.1016/j.yjmcc.2022.10.007

19. Identification of Potential Non-nucleoside MraY Inhibitors for Tuberculosis Chemotherapy from Structure-based Virtual Screening

Pandey, P.; Chatterjee, S.; Berida, Tomayo; Doerksen, R.J.; Roy, S.*

Journal of Biomolecular Structure & Dynamics, 2022, 40, 4832. DOI: 10.1080/07391102.2020.1862705

18. Optimization Rules for SARS-CoV-2 Mpro Antivirals: Ensemble Docking and Exploration of the Coronavirus Protease Active Site

Stoddard, S. V.;* Stoddard, S. D; Oelkers, B. K.; Fitts, K.; Whalum, K.; Whalum, K.; Hemphill, A. D.; Manikonda, J.; Martinez, L. M.; Riley, E. G.; Roof, C. M.; Sarwar, N.; Thomas, D. M.; Ulmer, E.; Wallace, F. E.; Pandey, P.; Roy, S.

Viruses, 2020, 12, 942. DOI: 10.3390/v12090942

17. Targeting RNA-binding Protein HuR to Inhibit Human Breast Cancer Invasion and Metastasis

Wu, X.; Gardashova, G.; Lan, L.; Han, S.; Zhong, C.; Marquez, R.; Wood, S.; Roy, S.; Gowthaman, R.; Karanicolas, J.; Gao, P.; Dixon, D.; Welch, D.; Li, L.; Ji, M.; Aubé, J.; Xu, L.*

Communications Biology, 2020, 3, 193. DOI: 10.1038/s42003-020-0933-1

16. Fluorinated 1,2,3-Triazoles from α-Fluoronitroalkenes as Surrogates of α-Fluoroalkynes via Regioselective Cycloaddition Reactions with Organic Azides

Jana, S.; Adhikari, S.; Cox, M. R.; Roy, S.*

Chemical Communications 2020, 56, 1871. DOI: 10.1039/C9CC09216A

15. HuR Reduces Radiation-Induced DNA Damage by Enhancing Expression of ARID1A

Andrade, D.; Mehta, M.; Griffith, J.; Oh, S.; Corbin, J.; Babu, A.; De, S.; Chen, A.; Zhao, Y. D.;Husain, S.; Roy, S.; Xu, L.; Aube, J.; Janknecht, R.; Gorospe, M.; Herman, T.; Ramesh, R.; Munshi, A.*

Cancers 2019, 11, 2014. doi:10.3390/cancers11122014.

14. The HuR CMLD-2 Inhibitor Exhibits Antitumor Effects via MAD2 Downregulation in Thyroid Cancer Cells

Allegri, L.; Baldan, F.*; Roy, S.; Aubé, J.; Russo, D.; Filetti, S.; Damante, G.

Scientific Reports 9, 2019, Article number: 7374.

13. Human antigen R as a therapeutic target in pathological cardiac hypertrophy

Green, L.G.; Anthony, S. R.; Slone, S.; Lanzillotta, L.; Nieman, M. L.; Wu, X.; Robbins, N,; Jones, S. M.; Roy, S.; Owens, A. P.; Aubé, J.; Xu, L.; Lorenz, J. N.; Blaxall, B. C.; Rubinstein, J.; Benoit, J. B.; Tranter, M.*

JCI Insight, 2019; 4(4):e121541.

12. Identification of Antimalarial Inhibitors Using Late-Stage Gametocytes in a Phenotypic Live/Dead Assay

Spicer, T. P.*; Gardiner, D. L.; Schoenen, F. J.; Roy, S.; Griffin, P. R.; Chase, P.; Scampavia, L.; Hodder, P.; Trenholme, K. R.

SLAS DISCOVERY: Advancing Life Sciences R&D, 2019, 24, 38–46.

11. Hexafluoroisopropanol and Acetyl Chloride Promoted Catalytic Hydroarylation with Phenols

Roy, S.; Motiwala, H. F.; Koshlap, K. M.; Aubé, J.*

European Journal of Organic Chemistry, 2018, 306–315.

10. HuR-targeted small molecule inhibitor exhibits cytotoxicity towards human lung cancer cells

Muralidharan, R.; Mehta, M.; Ahmed, R.; Roy, S.; Xu, L.; Aubé, J.; Chen, A.; Zhao, Y.; Herman, T.; Ramesh, R.*; Munshi, A.*

Scientific Reports, 7, 2017, Article number: 9694.

9. N-Phenylbenzamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore

Roy, S.; Sileikyte, J.; Neuenswander, B.; Hedrick, M. P.; Chung, T. D. Y.; Aubé, J.; Schoenen, F. J.*; Forte M. A.*; Bernardi, P.*

ChemMedChem, 2016, 11, 283–288.

8. Discovery, Synthesis, and Optimization of Diarylisoxazole-3-carboxamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore

Roy, S.; Sileikyte, J.; Schiavone, M.; Neuenswander, B.; Argenton, F.; Aubé, J.; Hedrick, M. P.; Chung, T. D. Y.; Forte M. A.; Bernardi, P.; Schoenen, F. J.

ChemMedChem, 2015, 10, 1655–1671.

7. A Practical and Scalable Synthesis of (S)- and (R)-1-(Dimethoxyphosphoryl)allyl Methyl Carbonates

Roy, S.; Sutivisedsak, N.; Hamper, B. C.; Lyss, A. M.; Spilling, C. D.

Synthesis, 2015, 47, 3669–3672.

6. Small Molecules Targeting the Mitochondrial Permeability Transition

Sileikyte, J.; Roy, S.; Porubsky, P.; Neuenswander, B.; Wang, J.; Hedrick, M.; Pinkerton, A. B.; Salaniwal, S.; Kung, P.; Mangravita-Novo, A.; Smith, L. H.; Bourdette, D. N.; Jackson, M. R.; Aubé, J; Chung, T. D. Y.; Schoenen, F. J.; Forte M. A.; Bernardi, P.

Probe Reports from the NIH Molecular Libraries Program. Submitted in April, 2014; Peer-reviewed in July, 2014.

5. Development of (E)-2-((1,4-dimethylpiperazin-2-ylidene)amino)-5-nitro-N-phenylbenzamide, ML336: Novel 2-Amidinophenylbenzamides as Potent Inhibitors of Venezuelan Equine Encephalitis Virus

Schroeder, C. E.; Yao, Y.; Sotsky, J.; Smith, R. A.; Roy, S.; Chu, Y-K, Guo, H.; Tower, N. A.; Noah, J. W.; McKellip, S.; Sosa, M.; Ramussen, L.; Smith, L. H.; White. E. L.; Aubé, J.; Jonsson, C. B.; Chung, D.; Golden, J. E.

Journal of Medicinal Chemistry, 2014, 57, 8608–8621.

4. ML336: Development of Quinazolinone-Based Inhibitors Against Venezuelan Equine Encephalitis Virus (VEEV)

Chung, D.; Schroeder, C. E.; Sotsky, J.; Yao, T.; Roy, S.; Smith, R. A.; Tower, N. A.; Noah, J. A.; McKellip, S.; Sosa, M.; Rasmussen, L.; White, E. L.; Aubé, J.; Golden, J. E.

Probe Reports from the NIH Molecular Libraries Program. Submitted in December, 2012; Peer-reviewed in February, 2013.

3. An Expeditious Total Synthesis of Both Diastereomeric Lipid Dihydroxytetrahydrofurans from Notheia Anomala

Roy, S.; Spilling, C. D.

Organic Letters, 2012, 14, 2230–2233.

2. Synthesis of the C(18)-C(34) Fragment of Amphidinolide C and the C(18)-C(29) Fragment of Amphidinolide F

Roy, S.; Spilling, C. D.

Organic Letters, 2010, 12, 5326–5329.